Stereoisomerism

Author
Jonas Bäckelin, Mikael Elias Gymnasium, Stockholm, Sweden
Type of School
Grades 9–12
Suitable for
Age 15+
Subject
Chemistry – Stereoisomerism
Duration
100 minutes
21st Century Skills
Visual communication, working with 3D animation
1
Lesson Overview

A chemistry lesson focused on stereoisomers. Encourage students to interact with the educational simulation/model rather than relying solely on textbook illustrations. Seeing molecules in 3D makes it much easier to understand cis-trans isomerism and chirality centers.

2
Lesson Objectives
  • Use a real-world example connected to isomerism, such as the pharmaceutical industry, and encourage students to develop the idea further and draw their own conclusions.
  • Through this process, students will gain a deeper understanding of how scientific concepts can be communicated and explored using the Corinth application.
3
Additional Resources, Applications and Technology
  • Computer, internet connection, textbook
  • Projector or a shared link in MS Teams
  • Mini whiteboards or OneNote Class Notebook
4
Lesson Outline (100 minutes)
  • 15 minutes
    Share the presentation link with students. Summarize isomerism on the board using the textbook.
  • 50 minutes
    Students begin creating their own examples of structural isomers using the Collaboration Space in OneNote Class Notebook. Different groups may be assigned different tasks and later present their findings to the class.
  • 20 minutes
    Using an interactive whiteboard or projector, display the animated 3D methane model in Corinth and explain that a carbon atom with four different substituents cannot be superimposed on its mirror image.

    methane (ball-and-stick model)

    Then show students the 3D methane model.

    Ask them to answer three poll questions, display their responses on the projector and discuss the results as a class. If a projector is not available, the teacher can read the responses aloud and lead the discussion.

    Repeat the same process using the Cis-trans Isomerism model.

    cis/trans isomerism
  • 15 minutes
    At the end of the lesson, students record their final notes in their OneNote notebooks. Their task is to summarize what they have learned and prepare questions for the next lesson.
5
3D Model – Chirality Centers (Methane)

Use this 3D methane model to demonstrate why a carbon atom with four different substituents cannot be superimposed on its mirror image and how a chirality center relates to stereoisomerism.

If the model does not load, open it directly:
app.corinth3d.com/content/c_hemi_methan

6
3D Model – Cis-trans Isomerism

Repeat the same procedure used for methane with the Cis-trans Isomerism model. Students compare the differences between cis and trans configurations and discuss how these structural changes influence the properties of molecules.

If the model does not load, open it directly:
app.corinth3d.com/content/c_hemi_r15_izometrie

7
Conclusion and Reflection

At the end of the lesson, students record their final notes in their OneNote notebooks. Their task is to summarize what they have learned and prepare questions for the next lesson.

Open Corinth App